为了确定3号染色体长臂(3q)结构重排在恶性血液病中的频率和意义,作者对他们医院过去12年间发现的24例伴有3q异常的恶性血液病患者的临床、血液学和细胞遗传学资料作了回顾性分析。 该院自1978年1月至1990年12月间共收治2000例各类恶性血液病,其中1200例(60％)伴有克隆性染色体异常,24例(2％)系获得性3q结构重排。患者中数年龄59岁,男13例,女11例。其临床类型包括急性髓性白血病(AML)13例,骨髓增生异 To determine the frequency and significance of the rearrangement of the long arm (3q) structure of chromosome 3 in hematologic malignancies, the authors evaluated the clinical, hematological, and cellular features of 24 patients with 3q-associated hematologic malignancies found in their hospital over the past 12 years Genetics data made a retrospective analysis. The hospital from January 1978 to December 1990 were treated 2000 cases of various types of hematological malignancies, of which 1200 cases (60%) with clonal chromosomal abnormalities, 24 cases (2%) acquired 3q structural rearrangement . The number of patients aged 59 years, 13 males and 11 females. The clinical types include acute myeloid leukemia (AML) in 13 cases, myelodysplasia