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探讨卵巢癌患者血浆中Th1/Th2类细胞因子失调及其临床意义。方法 :用ELISA法检测了 2 5例卵巢癌及 15例健康妇女血浆中IL - 2、IFN -γ、IL - 6和IL - 10水平。结果 :卵巢癌患者较健康妇女血浆中IL - 2水平明显降低 ,而IL - 6和IL - 10明显升高 ,且这种变化随临床期别的升高更加明显。结论 :卵巢癌患者外周血中Th1/Th2类细胞因子失调 ,在卵巢癌的发生发展中可能起重要作用。
To investigate the imbalance of Th1 / Th2 cytokines in the plasma of patients with ovarian cancer and its clinical significance. Methods: The levels of IL - 2, IFN - γ, IL - 6 and IL - 10 in 25 cases of ovarian cancer and 15 healthy women were detected by ELISA. Results: The levels of IL - 2 in plasma of patients with ovarian cancer were significantly lower than those in healthy women, while the levels of IL - 6 and IL - 10 were significantly higher in patients with ovarian cancer than those in healthy individuals. Conclusion: The imbalance of Th1 / Th2 cytokines in the peripheral blood of ovarian cancer patients may play an important role in the development of ovarian cancer.