论文部分内容阅读
[目的]观察氟接触人群血清中人硬骨素(sclerostin,SOST)的水平,分析其与碱性磷酸酶(alkalinephosphatase,ALP)及氟性骨损伤的相关性,探讨SOST在氟性骨损伤发生中的作用及其机制。[方法]采用问卷调查氟接触人群的一般情况、既往史及现患疾病情况,采集静脉血检测SOST、ALP、血氟等指标,并对其进行前臂正位X线检查,采用SPSS 18.0统计软件对数据进行统计学分析。[结果]高氟组SOST为(4.806±0.525)μg/L,与中氟组和低氟组比较差异有统计学意义(P<0.01);高氟组的SOST阳性率为25.0%,与低氟组相比差异有统计学意义(P<0.05);损伤组、未损伤组和对照组的SOST分别为(4.870±0.504)μg/L、(5.100±0.627)μg/L和(5.234±0.603)μg/L,损伤组与对照组相比差异有统计学意义(P<0.05);高氟区对象血清SOST与ALP之间的线性相关系数为-0.319(P=0.001);血清SOST与氟性骨损伤密切相关,SOST阳性者患氟性骨损伤的风险是SOST阴性者的2.417倍(P<0.05)。[结论]氟接触人群SOST明显降低,SOST与ALP活性及氟性骨损伤的发生发展有关,降低的SOST可能参与骨代谢及骨损伤过程,其确切机制有待进一步深入研究。
[Objective] To observe the serum levels of sclerostin (SOST) in fluoride exposure groups, analyze its correlation with alkaline phosphatase (ALP) and fluorosis bone injury, and to explore the role of SOST in the occurrence of fluorosis bone injury The role and mechanism. [Methods] The questionnaires were used to investigate the general situation, previous history and prevalence of disease in the population exposed to fluoride. Venous blood samples were collected for the detection of SOST, ALP, blood fluoride and other indicators, and their forearm X-rays were examined. SPSS 18.0 statistical software The data were statistically analyzed. [Results] The SOST in high fluoride group was (4.806 ± 0.525) μg / L, which was significantly lower than that in medium fluoride group and low fluoride group (P <0.01). The positive rate of SOST in high fluoride group was 25.0% (4.70 ± 0.504) μg / L, (5.100 ± 0.627) μg / L and (5.234 ± 0.603, P <0.05) respectively in the injury group, the uninjured group and the control group ) μg / L, the difference between the injury group and the control group was statistically significant (P <0.05). The linear correlation coefficient between serum SOST and ALP was -0.319 (P = 0.001) Bone injury is closely related to the risk of FOS bone injury in patients with SOST positive 2.417 times that of SOST negative (P <0.05). [Conclusions] The SOST of fluorine-exposed group is significantly lower, the activity of SOST is related to the activity of ALP and the occurrence and development of FFA, and the decreased SOST may be involved in the process of bone metabolism and bone damage. The exact mechanism remains to be further studied.