青春期开始的特征为垂体促性腺激素出现分泌脉冲,此依赖于下丘脑促黄体生成素释放激素(LHRH)释放的脉冲。LHRH 释放的节律和持续时间是主要生物学活性的关键。长期应用促黄体生成素释放激素类似物(LHRH—A)通过对垂体受体下降调节而抑制促性腺激素的分泌,从而可以治疗中枢性性早熟,但Rosen(?)hal 等报道的另一种男性 The onset of puberty is characterized by the secretion of pituitary gonadotropin, which relies on the release of pulses from the hypothalamic luteinizing hormone-releasing hormone (LHRH). The rhythm and duration of LHRH release are the key to the primary biological activity. Long-term use of LHRH-A (LHRH-A) can treat central precocious puberty by inhibiting the secretion of gonadotropin through the down-regulation of pituitary receptors, but the other reported by Rosen (?) Hal et al male