Reversed magnetic shear (RS) plasma configuration with internal transport barrier (ITB) is one of the most promising ways to achieve high performance regimes in Tokamaks. It has improved stability to some macro-instability modes, such as the ballooning modes and nco-classical tearing modes. Nevertheless, resistive interchange modes can be driven unstablely by large pressure in the reversed magnetic shear region, which would deteriorate the high plasma performance in the central region. To identify the instability regime, the resistive interchange instability is analyzed for a specific RS configuration formed with neutral beam injection Reversed magnetic shear (RS) plasma configuration with internal transport barrier (ITB) is one of the most promising ways to achieve high performance regimes in Tokamaks. It has improved stability to some macro-instability modes, such as the ballooning modes and nco-classical Nevertheless, resistive interchange modes can be driven unstable to large pressure in the middle region. configuration formed with neutral beam injection