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目的:了解南京地区抗真菌药的利用情况和发展趋势,为临床合理使用抗真菌药提供参考。方法:采用限定日剂量法,对本地区34家医院2013~2015年抗真菌药的销售金额、用药频度(DDDs)和限定日费用(DDC)等进行回顾性分析。结果:2013~2015年抗真菌药的销售金额逐年上升,增长率最高达41.13%;三唑类药物的销售金额连续三年居首位,占所有抗真菌药销售金额的60%以上;2013~2015年伏立康唑、氟康唑、伊曲康唑和卡泊芬净居销售金额的前4位;克霉唑外用剂型、伊曲康唑口服剂型保持DDDs的前2位;临床使用量较大的抗真菌药集中于唑类和烯丙胺类;DDC值居前三位的是卡泊芬净、米卡芬净和伏立康唑注射液。结论:2013~2015年抗真菌药的临床使用量持续攀升,侵袭性真菌感染是高危致命因素,合理使用抗真菌药是临床治疗的首要原则。
Objective: To understand the use of antifungal agents in Nanjing and its development trend, to provide a reference for the rational use of antifungal agents in clinical practice. Methods: The daily dose method was used to retrospectively analyze the antifungal sales, medication frequency (DDDs) and DDC between 2013 and 2015 in 34 hospitals in the region. Results: The sales volume of antifungal drugs increased year by year from 2013 to 2015, with the highest growth rate of 41.13%. The sales volume of triazole drugs ranked the first among the three consecutive years, accounting for more than 60% of the total antifungal sales value. 2015 voriconazole, fluconazole, itraconazole and caspofungin net sales of the top 4; clotrimazole topical dosage forms, itraconazole oral dosage forms to maintain DDDs in the first two; clinical use of larger Antifungal agents focused on azoles and allylamines; the top three DDC values were caspofungin, micafungin and voriconazole. Conclusion: The clinical use of antifungal drugs keeps rising from 2013 to 2015. Invasive fungal infection is a risk factor of high risk. Rational use of antifungal agents is the first principle of clinical treatment.