本文报道了一种实用、高效的脂质体与抗体共价偶联的方法—戊二醛法。探索了不同比例的脂、不同戊二醛浓度和不同类型脂质体的偶联情况。并把抗胃癌细胞的单克隆抗体共价偶联到脂质体外层,与胃癌细胞进行了结合实验。研究了碱性磷酸酶(AKP)和辣根过氧化物酶(HRP)与脂质体偶联后对其活性的影响。电镜观察了偶联后脂质体的形态。 This paper reports a practical and efficient method for the covalent coupling of liposomes and antibodies - the glutaraldehyde method. Explore the different proportions of lipid, different concentrations of glutaraldehyde and the coupling of different types of liposomes. The anti-gastric cancer monoclonal antibody was covalently coupled to the outer layer of liposomes, and the binding experiments were performed with gastric cancer cells. The effects of alkaline phosphatase (AKP) and horseradish peroxidase (HRP) on liposomes were investigated. Electron microscopy showed the morphology of the liposomes after coupling.