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利用放射性~(99m)Tc标记HpD,在对带有膀胱肿瘤的裸鼠进行肿瘤组织和正常组织内HpD的分布水平和相对放射性强度研究的基础上,对50例膀胱肿瘤及14例非肿瘤患者作静注~(99m)Tc-HpD后的放射显像,另对10例膀胱肿瘤患者行静注游离~(99m)TeO_4-的放射显像对照。结果表明:50例肿瘤患者中,41例表现为异常(82％);14例非肿瘤患者中,12例表现正常(86％),有显著性差异(P<0.05)。10例~(99m)TcO_4-受检肿瘤患者中表现出与~(99m)Tc-HpD不同的放射性分布类型,与~(99m)Tc-HpD组相比,有非常显著性差异(P<0.001)。
Using radioactive 99mTc labeled HpD, on the basis of studies on the distribution and relative radioactivity of HpD in tumor tissues and normal tissues of nude mice bearing bladder tumors, 50 cases of bladder tumors and 14 cases of non-tumor patients Intravenous radiographs with ~(99m)Tc-HpD were performed intravenously. In addition, 10 patients with bladder tumors underwent intravenous injection of free 99m TeO_4-radioactive imaging. The results showed that among the 50 tumor patients, 41 were abnormal (82%); of the 14 non-tumor patients, 12 were normal (86%), with significant differences (P<0.05). The radioactivity distribution patterns of ~(99m)Tc-HpD were different in 10 patients with ~(99m)TcO_4- examined tumors, and were significantly different from the ~(99m)Tc-HpD group (P<0.001). ).