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维持基因组的稳定性是保证生命活动正常进行的必要条件。内部或外界的刺激会造成DNA的损伤,引起基因组的不稳定,导致细胞死亡甚至肿瘤发生。DNA为基础的核小体上的组蛋白可以发生多种翻译后修饰,其中组蛋白H3第36位上的赖氨酸(H3K36)的甲基化修饰在抑制非正常转录起始、抑制组蛋白交换、调控RNA可变剪切中发挥重要作用。近几年来,多项研究结果也表明,H3K36修饰在双链断裂和错配修复等DNA损伤修复活动中也发挥了调控作用。因此,了解H3K36甲基化在DNA损伤修复中的作用,可为相关疾病的研究与治疗提供理论基础。
Maintaining the stability of the genome is a necessary condition for ensuring the normal functioning of life. Internal or external stimuli can cause DNA damage, causing genomic instability, leading to cell death and even tumorigenesis. A variety of post-translational modifications can occur to histones on DNA-based nucleosomes, in which methylation modification of lysine (H3K36) at position 36 of histone H3 inhibits the initiation of abnormal transcription, inhibits histone Exchange, regulate RNA variable shear play an important role. In recent years, a number of studies have shown that the H3K36 modification also plays a regulatory role in DNA damage repair activities such as double-strand breaks and mismatch repair. Therefore, to understand the role of H3K36 methylation in DNA damage repair can provide a theoretical basis for the research and treatment of related diseases.