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目的分析早产儿呼吸窘迫综合征合并早期感染的临床表现及预后。方法 69例呼吸窘迫综合征早产患儿,39例合并早期感染者为观察组,30例未合并早期感染者为对照组,比较2组呼吸机辅助通气吸气峰压、机械通气时间以及气胸、肺出血、支气管肺发育不良发生率和病死率。结果观察组气胸发生率(12.8%)、病死率(10.2%)与对照组(6.7%、3.3%)比较差异均无统计学意义(P>0.05),呼吸机吸气峰压[(22±6)cm H2O]、机械通气时间[(6.7±3.8)d]、肺出血发生率(28.2%)、支气管肺发育不良发生率(69.2%)高于对照组[(18±7)cm H2O、(4.9±3.1)d、6.7%、36.7%](P<0.05)。结论早期感染可加重早产呼吸窘迫综合征患儿肺部疾病病情,应及早预防。
Objective To analyze the clinical manifestations and prognosis of respiratory distress syndrome complicated with early infection in premature infants. Methods 69 cases of premature infants with respiratory distress syndrome, 39 cases of early infection were observed group and 30 cases of early infection as control group. Ventilator assisted ventilation peak pressure, duration of mechanical ventilation and pneumothorax, Pulmonary hemorrhage, incidence of bronchopulmonary dysplasia and mortality. Results The pneumothorax incidence (12.8%) and mortality (10.2%) in the observation group were not significantly different from those in the control group (6.7%, 3.3%) (P> 0.05) (6.7 ± 3.8) d], the incidence of pulmonary hemorrhage (28.2%) and the incidence of bronchopulmonary dysplasia (69.2%) were higher than that of the control group [(18 ± 7) cm H2O, (4.9 ± 3.1) d, 6.7%, 36.7%] (P <0.05). Conclusion Early infection can aggravate lung disease in children with premature respiratory distress syndrome and should be prevented as soon as possible.