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目的研究并探讨误服过量对乙酰氨基酚导致肝衰竭死亡的病例。方法我院于2012年5月收治了误服过量对乙酰氨基酚致肝衰竭死亡的患者1例,对其临床资料进行较为科学与全面的回顾性分析。结果患者在服用过量的对乙酰氨基酚之后出现了恶心、呕吐等临床症状,患者的实验室检查结果为:患者的丙氨酸转氨酶7385U/L,总胆红素水平为26.5μmol/L,直接胆红素水平为15.5μmol/L,血酸乳的水平值为4.0μmol/L,凝血酶元活动度为22.9%,患者的临床诊断为肝衰竭。患者在经过5d的临床治疗之后,病情仍无好转,并于入院之后的第6天死亡。结论服用过量的对乙酰氨基酚将会导致患者出现急性肝衰竭,严重的还将导致患者的死亡。所以,有关部门应该加强对该药物的管理,避免长期重复用药,保障患者的健康。
Objective To study and explore the cases of excessive fat intake of paracetamol leading to death of liver failure. Methods In our hospital in May 2012, one patient who died of hepatic failure due to excessive oral administration of paracetamol was admitted to our hospital. The clinical data were analyzed retrospectively in a scientific and comprehensive manner. Results After taking acetaminophen overdose, the patients experienced clinical symptoms such as nausea and vomiting. The results of laboratory tests were as follows: patients with alanine aminotransferase 7385U / L, total bilirubin level 26.5μmol / L, direct The level of bilirubin was 15.5μmol / L, the level of blood yoghurt was 4.0μmol / L, the activity of thrombin was 22.9%, and the clinical diagnosis was liver failure. After 5 days of clinical treatment, the patient’s condition did not improve and died on the 6th day after admission. Conclusion Overdose of acetaminophen will result in acute liver failure in patients and severe death in patients. Therefore, the relevant departments should strengthen the management of the drug, to avoid long-term repeated medication, to protect the health of patients.