论文部分内容阅读
目的 :通过贲门癌高、低发区 1975例无症状居民普查 ,进一步了解贲门上皮病变的特征及其与性别、年龄的关系 ,加深对贲门癌变多阶段演进的形态学变化特征的了解。方法 :对食管癌高发区 10 0 6无症状居民 ,低发区 2 0 8无症状居民进行纤维内镜检查、粘膜活检和组织病理检查。结果 :高发区 10 0 6例活检标本中 ,共发现 9例早期贲门腺癌患者 (GCA ,0 .9% ) ,33例间变患者 (DYS ,3.3% ) ,10 2例慢性萎缩性贲门炎患者 (CAG ,10 .1% )和2 6 9例慢性浅表性贲门炎患者 (CSG ,2 6 .7% ) ,以及 5 93例正常贲门上皮 (NOR ,5 8.9% )。 9例早期GCA均发生在男性 ,间变患者男性明显高于女性 ;低发区 :2 0 8例普查对象中 ,未发现早期GCA ,但发现 2例DYS(1.0 % ) ,7例CAG(3.4 % ) ,118例CSG(5 6 .7% )和 81例正常贲门上皮 (38.9% )。男性CAG较女性常见 ,2例DYS中 ,男女各 1例。结论 :贲门癌高发区居民GCA、DYS、CAG的发现率明显高于低发区 ,进一步证实贲门癌的地域性分布特征 ,提示DYS和CAG是贲门癌重要的癌前病变
Objective : To investigate the characteristics of cardiac supratentorial epithelial lesions and their relationship with gender and age through 1975 asymptomatic census of high and low prevalence of cardiac cancers, and to deepen understanding of the morphological changes in the multistage evolution of cardiac cancer. METHODS: Fibrous endoscopy, mucosal biopsy, and histopathologic examination were performed on asymptomatic residents with high incidence of esophageal cancer in 106 cases and asymptomatic residents in low-risk areas. RESULTS: Among the 106 cases of biopsy specimens in the high-incidence area, 9 cases were diagnosed as early GCA (GCA, 0.9%), 33 cases were intermetastatic (DYS, 3.3%), and 102 cases of chronic atrophic cardiomyopathy. Patients (CAG, 10.1%) and 269 patients with chronic superficial cardia- physitis (CSG, 26.7%), and 5 93 cases of normal cardia-epithelial (NOR, 5 8.9%). Nine cases of early GCA occurred in males, and males in patients with metastasis were significantly higher than those in females; low incidence regions: Among 28 subjects, no early GCA was found, but 2 cases of DYS (1.0%) and 7 cases of CAG (3.4) were found. %), 118 cases of CSG (56.7%) and 81 cases of normal cardia epithelium (38.9%). Male CAG was more common in women than in females, and in 2 cases of DYS, 1 male and 1 female. Conclusion: The rates of GCA, DYS and CAG in residents with high prevalence of cardiac cancer were significantly higher than those in low incidence areas, further confirming the regional distribution of cardiac cancer, suggesting that DYS and CAG are important precancerous lesions of cardiac cancer.