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【目的】研究儿童白血病的环境危险因素,为临床有效干预提供参考依据。【方法】自行设计白血病危险因素调查表,对2004年7月—2008年12月期间在温州医学院附属育英儿童医院住院及登记的141例0～14岁白血病患儿进行l∶l配对病例对照研究,对所得资料进行单因素分析,选择其中有意义的进行多因素条件Logistic回归分析。【结果】84项指标单因素分析中有15项有统计学意义;其中患白血病前频繁感染、经常吃腌制食品、父亲经常接触有机溶剂、母亲孕期感染、母亲孕期经常接触石油产品、住房周围空气污染、住宅装修入住后有气味、居住地附近有变电所、居住地附近有信号发射塔9项指标在多因素条件Logistic逐步回归分析中有统计学意义。【结论】环境中的物理、化学、生物因素与儿童白血病关联。
【Objective】 To study the environmental risk factors of childhood leukemia and provide a reference for clinical effective intervention. 【Methods】 A self-designed questionnaire of risk factors for leukemia was designed. One hundred and seventy-one matched cases of children with 0- to 14-year-old leukemia hospitalized and registered in Yuying Children’s Hospital Affiliated to Wenzhou Medical College from July 2004 to December 2008 were enrolled Study, single-factor analysis of the resulting data, select one of the significance of multi-factor conditional Logistic regression analysis. 【Results】 There were 15 items in 84 items of univariate analysis were statistically significant. Among them, there were frequent infection before leukemia, frequent eating of preserved food, frequent exposure of father to organic solvent, infection of mother during pregnancy, frequent exposure of mother to petroleum products during pregnancy, Air pollution, residential decoration odor after living, living near the substation, living near the signal tower 9 indicators in the multivariate conditional Logistic stepwise regression analysis was statistically significant. 【Conclusion】 The physical, chemical and biological factors in the environment are associated with childhood leukemia.