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目的研究细胞外基质金属蛋白酶诱导因子(CD147)在膀胱癌组织中的表达情况,探讨其临床意义。方法应用免疫组织化学SP法检测58例膀胱癌组织,20例正常膀胱组织和15例胚胎膀胱组织中CD147的表达情况,并对CD147与膀胱癌临床病理的关系进行统计学分析。结果胚胎膀胱组织、正常膀胱组织、膀胱癌组织CD147阳性率分别为0、5.0%、70.7%。膀胱癌与其他两组比较,差异有统计学意义(P<0.01)。CD147蛋白的表达与肿瘤的TNM分期和浸润程度有关。结论 CD147有可能成为判断膀胱癌侵袭力的重要指标,有望成为反映肿瘤恶性程度及预后判断的标记物。
Objective To investigate the expression of extracellular matrix metalloproteinase inducer (CD147) in bladder cancer and to explore its clinical significance. Methods Immunohistochemical SP method was used to detect the expression of CD147 in 58 cases of bladder cancer, 20 cases of normal bladder tissue and 15 cases of embryonic bladder tissue. Statistical analysis was made on the relationship between CD147 and clinicopathological features of bladder cancer. Results The positive rates of CD147 in embryo bladder, normal bladder and bladder cancer were 0, 5.0% and 70.7% respectively. Bladder cancer and other two groups, the difference was statistically significant (P <0.01). CD147 protein expression and tumor TNM staging and infiltration degree. Conclusion CD147 may be an important index for judging the invasiveness of bladder cancer and is expected to become a marker of tumor malignancy and prognosis.