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目的提醒临床重视米诺环素所致的药物不良反应(ADR)。方法对1例布鲁氏菌病感染患者应用米诺环素治疗时所发生的ADR过程进行分析。结果患者用药至第25天时,出现呼吸道症状、嗜酸性粒细胞增高胸片提示嗜酸性粒细胞性肺炎。在停用米诺环素并经抗过敏治疗13 d后,患者临床症状减轻,嗜酸性粒细胞降至正常。患者于再次服用米诺环素的次日,再次出现嗜酸性粒细胞升高,考虑为米诺环素相关急性嗜酸性粒细胞性肺炎。结论米诺环素引起急性嗜酸性粒细胞性肺炎较为严重,因此应关注患者症状和体征,注意监测全血细胞计数,确保临床用药安全。
Objective To remind the clinical attention of minocycline-induced adverse drug reaction (ADR). Methods One case of brucellosis infection in patients with minocycline in the treatment of ADR process was analyzed. Results The patient developed respiratory symptoms by day 25 and increased eosinophilia revealed eosinophilic pneumonia. After stopping minocycline and anti-allergic treatment for 13 days, the clinical symptoms of the patients were alleviated and the eosinophils were reduced to normal. Patients again taking minocycline the next day, again eosinophilia, consider minocycline-related acute eosinophilic pneumonia. Conclusion Minocycline caused acute eosinophilic pneumonia is more serious, so should pay attention to the symptoms and signs of patients, pay attention to monitoring the whole blood count to ensure the safety of clinical medication.