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目的探讨人微小病毒B19感染与胃十二指肠疾病之间的相关性。方法收集139例幽门螺杆菌感染的胃十二指肠疾病患者血液,其中慢性浅表性胃炎65例,消化性溃疡74例;同时收集128例健康体检人群血液作为对照,利用聚合酶链反应法检测两组样本中人微小病毒B19 DNA阳性率。结果 139例胃十二指肠疾病患者中,B19 DNA阳性率为10.07%(14/139),而128例健康体检标本中,B19 DNA阳性率为1.56%(2/128),两组之间差异有统计学意义(P<0.01)。比较消化性溃疡组和慢性浅表性胃炎组中B19病毒感染率,结果显示消化性溃疡组病毒阳性率高于慢性浅表性胃炎组(12.16%vs 7.69%),两者与对照组比较差异有统计学意义,但两者间相互比较差异无统计学意义(P>0.05)。结论微小病毒B19存在于胃十二指肠疾病患者的血液中,可能与人胃十二指肠疾病的发展密切相关。
Objective To investigate the correlation between human parvovirus B19 infection and gastroduodenal diseases. Methods Blood was collected from 139 patients with gastroduodenal diseases with Helicobacter pylori infection, including 65 cases of chronic superficial gastritis and 74 cases of peptic ulcer. At the same time, blood samples were collected from 128 healthy people as controls, and polymerase chain reaction The positive rate of human parvovirus B19 DNA in two samples was tested. Results Among 139 cases of gastroduodenal diseases, the positive rate of B19 DNA was 10.07% (14/139), while the positive rate of B19 DNA was 1.56% (2/128) in 128 healthy volunteers. Between the two groups, The difference was statistically significant (P <0.01). Comparing the infection rate of B19 virus in peptic ulcer group and chronic superficial gastritis group, the positive rate of virus in peptic ulcer group was higher than that in chronic superficial gastritis group (12.16% vs 7.69%), the difference between them There was statistical significance, but there was no significant difference between them (P> 0.05). Conclusions Parvovirus B19 is present in the blood of patients with gastroduodenal diseases and may be closely related to the development of human gastroduodenal diseases.