采用ELISA(enzyme linkedimmunoadsordentassay)法检测16例新疆经典型卡波氏肉瘤(Kaposi’ssarcoma,KS)及64例正常对照的血清中IL 6、VEGF、TNF α和IFN γ血清浓度。探究了经典型卡波氏肉瘤发病机制与血清中白细胞介素(interleukin 6,IL 6)、血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)、肿瘤坏死因子(tumornecrosisfactor α,TNF α)、干扰素γ(interferon,IFN γ)紊乱之间的关系。研究结果表明:血清IL 6、VEGF和TNF α在KS病例组与对照组之间差异具有显著性(P值分别为0.040、0.002和0.043)。IFN γ在KS病例组与对照组之间差异无显著性,P值为0.067。这说明,血清IL 6、VEGF、TNF α的紊乱与经典型KS的发生存在一定的关系。 Serum levels of IL 6, VEGF, TNFα and IFNγ in 16 cases of Kaposi’s sarcoma (KS) and 64 normal controls were detected by enzyme linked immunosorbent assay (ELISA). To investigate the relationship between the pathogenesis of classical Kaposi’s sarcoma and the levels of serum interleukin 6 (IL 6), vascular endothelial growth factor (VEGF), tumor necrosis factor α (TNFα), interferon , IFN γ) disorders. The results showed that the serum levels of IL-6, VEGF and TNF-α were significantly different between KS group and control group (P = 0.040, 0.002 and 0.043, respectively). There was no significant difference in IFN γ between KS group and control group, P value was 0.067. This shows that the serum IL 6, VEGF, TNFα disorder and the occurrence of classical KS there is a certain relationship.