结直肠癌是常见的恶性肿瘤,近年来我国结直肠癌的发病率和死亡率均呈上升趋势,对其发病机制研究的重要性渐为人们认识涉及了多基因改变,微卫星不稳定性,细胞凋亡机能受限,端粒酶活化以及多条信号传导通路异常等。近期分子学研究发现,DNA修复基因突变引起DNA错配修复系统的功能 Colorectal cancer is a common malignant tumor. In recent years, the morbidity and mortality of colorectal cancer in our country have been on the rise. The importance of studying the pathogenesis of colorectal cancer is gradually becoming more and more important to people’s understanding of multi-gene change, microsatellite instability, The function of apoptosis is limited, telomerase activation and abnormality of many signal transduction pathways and so on. Recent molecular studies have found that DNA repair gene mutations cause DNA mismatch repair system functions