Objective:The objective of the present study was to develop floating microspheres of Cefpodoxime Proxetil in order to achieve an extended retention in the upper GIT,which may result in enhanced absorption and there by improved bioavailability.Methods:The microspheres were prepared by non - aqueous solvent evaporation method using polymers such as Hydroxyl Propyl Methyl Cellulose(HPMC K15M),Ethyl Cellulose(EC) in different ratios,and Cefpodoxime Proxetil contain in each formulation.In vitro drug release were performed by USP apparatus type I andthe microspheres were characterized by calculating percentage yield,particle size analysis, buoyancy percentage,drug entrapment efficiencyand in vitro drug release studies.Results:The result showed microspheres yield were 50.50%-72.21%,particle size were distributed between75-600μm,drug entrapment efficiency were 14.1%-28.2%,buoyancy percentage were 70.10%-88.25%.Conclusion: Cefpodoxime Proxetil floating microspheres,at the lower polymer to drug ratio,there was a significant drug release. The better drug release profile was seen with FA_2 with ratio of drug polymer(1:2). Objective: The objective of the present study was to develop floating microspheres of Cefpodoxime Proxetil in order to achieve extended retention in the upper GIT, which may result in enhanced absorption and there by improved bioavailability. Methods: The microspheres were prepared by non - aqueous solvent evaporation method using polymers such as Hydroxyl Propyl Methyl Cellulose (HPMC K15M), Ethyl Cellulose (EC) in different ratios, and Cefpodoxime Proxetil contain in each formulation. In vitro drug release were performed by USP apparatus type I and the microspheres were characterized by calculating Percent yield, particle size analysis, buoyancy percentage, drug entrapment efficiency and in vitro drug release studies. Results: The result showed microspheres yield were 50.50% -72.21%, particle size were distributed between 75-600 μm, drug entrapment efficiency were 14.1% -28.2% , buoyancy percentage were 70.10% -88.25% .Conclusion: Cefpodoxime Proxetil floating microspheres, at the lower polymer to drug ratio, there was a significant drug release. The better drug release profile was seen with FA_2 with ratio of drug polymer (1: 2).