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目的调查阜宁地区妇女人乳头状瘤病毒(HPV)感染况状、基因分型及年龄特点。方法采用实时荧光多重PCR技术,对2016年1月-2017年1月在阜宁县人民医院体检和在妇科筛查宫颈癌的2 292例妇女的宫颈上皮细胞进行HPV检测并进行基因分型。结果 2 292例妇女宫颈上皮细胞HPV检出率为27.0%,其中高危型HPV的检出率为24.5%,以HPV-58型最高,占15.8%,其次为HPV-16型、HPV-52型。低危型HPV的检出率为6.6%。单一型别的感染率为17.5%,多重感染率为9.5%。年龄组分布为36岁~45岁感染率最高,为35.2%,其次为46岁~55岁、26岁~35岁,感染率分别为28.9%、23.3%。结论阜宁地区女性HPV感染的年龄分布和基因亚型分布具有自身的流行病特点。应加强妇女的HPV筛查力度,特别是26岁~55岁的妇女,为HPV分子流行病学和宫颈癌的防治提供依据。
Objective To investigate the status, genotyping and age characteristics of human papillomavirus (HPV) infection in Funing area. Methods Real-time fluorescence multiplex PCR was used to detect HPV genotypes in 2 292 women’s cervical epithelial cells from Futian People’s Hospital from January 2016 to January 2017 and from gynecological screening cervical cancer. Results The detection rate of HPV was 27.0% in 2 292 cases of women. The detection rate of high-risk HPV was 24.5%, the highest was HPV-58, accounting for 15.8%, followed by HPV-16 and HPV-52 . The detection rate of low-risk HPV was 6.6%. The infection rate of single type was 17.5% and the multiple infection rate was 9.5%. The highest infection rate was 35.2% in the age group from 36 to 45 years old, followed by 46 to 55 years old and 26 to 35 years old. The infection rates were 28.9% and 23.3% respectively. Conclusion The age distribution and genotype distribution of female HPV infection in Funing area have their own epidemic characteristics. Women should be strengthened screening of HPV, in particular, 26-year-old to 55-year-old women, HPV molecular epidemiology and cervical cancer prevention provide the basis.