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【目的】探索经新生儿疾病筛查程序诊治的先天性甲状腺功能减低症(congenital hypothyroidism,CH)智力特点,分析其与疾病本身及治疗因素的关系,为正确评估预后、探索更完善的治疗方案提供依据。【方法】以7～18岁CH56例为研究对象,用韦氏智力诊断量表(C-WISC)进行智力测查,结果与正常人群标准值比较,应用SPSS13.0进行统计学分析。【结果】CH智商与正常人群标准值(100±15)比较差异无统计学意义(P>0.05);其与诊断时T4水平、甲状腺组织发育情况及治疗初期甲状腺功能恢复情况呈显著或非常显著正相关(r=0.336～0.660,P=0.024～0.000),与治疗年龄呈负相关(r=0.295,P=0.049)。【结论】CH智力分布特点与正常人群一致;病情程度及治疗初期甲状腺功能恢复情况是影响智力发育的重要因素。
【Objective】 To explore the intelligence characteristics of congenital hypothyroidism (CH) diagnosed and treated by neonatal disease screening program, to analyze its relationship with the disease itself and the treatment factors, to explore a better treatment plan for the correct prognosis evaluation Provide evidence. 【Methods】 CH56 cases aged 7-18 years old were selected as the research objects. The intelligence tests were performed with C-WISC. The results were compared with those of the normal population. SPSS 13.0 was used for statistical analysis. 【Results】 There was no significant difference between the standard value of IQ and normal group (100 ± 15) (P> 0.05), which was significantly or very significantly correlated with the level of T4, the development of thyroid tissue and the recovery of thyroid function during the initial treatment (R = 0.336-0.660, P = 0.024-0.000), and was negatively correlated with the treatment age (r = 0.295, P = 0.049). 【Conclusion】 The distribution of CH intelligence is consistent with that of the normal population. The severity of illness and the recovery of thyroid function during the initial treatment are the important factors that affect the mental development.