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目的检测慢性非细菌性前列腺炎(CAP)患者精浆中细胞因子白介素2(IL-2)、白介素6(IL-6)、白介素8(IL-8)、白介素10(IL-10)、肿瘤坏死因子α(TNF-α)的水平,探讨这些细胞因子对CAP诊断价值。方法按美国国立卫生研究院(NIH)分类法将57例慢性非细菌性前列腺炎患者分为ⅢA组25例,ⅢB组32例。采用酶联免疫吸附测定法(ELISA)测定患者精浆中IL-2、IL-6、IL-8、IL-10、TNF-α的水平,并以18例健康男性为对照。结果ⅢA组、ⅢB组与对照组比较,精浆中IL-2、IL-6、IL-8、TNF-α含量显著升高,组间比较(P<0.01),IL-10含量显著降低,组间比较(P<0.01)。结论精浆中细胞因子IL-2、IL-6、IL-8、TNF-α水平升高及IL-10水平降低对慢性非细菌性前列腺炎诊断一定的价值。
Objective To detect the levels of interleukin 2 (IL-2), interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10), tumor in patients with chronic non-bacterial prostatitis (TNF-α) levels, to explore the diagnostic value of these cytokines on CAP. Methods According to the National Institutes of Health (NIH) classification, 57 patients with chronic nonbacterial prostatitis were divided into group ⅢA 25 cases, group ⅢB 32 cases. Serum levels of IL-2, IL-6, IL-8, IL-10 and TNF-α were measured by enzyme-linked immunosorbent assay (ELISA) in 18 healthy men. Results Compared with the control group, the contents of IL-2, IL-6, IL-8 and TNF-α in group ⅢA and group ⅢB were significantly increased (P <0.01) Comparison between groups (P <0.01). Conclusion Seminal plasma cytokines IL-2, IL-6, IL-8, TNF-α levels and IL-10 levels reduce the diagnosis of chronic non-bacterial prostatitis a certain value.