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维生素利用一直是科学家及医学工作者所热衷的主题 ,与人类健康息息相关。目前已发现某些水溶性维生素的吸收过程是由专有的转运体介导的。本文主要综述了泛酸、生物素、硫辛酸共用的转运体的基因结构 ,蛋白质结构、组织分布、克隆表达后的功能特点、染色体定位及转运过程的调控 ,此转运体因三种维生素共用而称多维生素转运体 (SMVT) ,有着明显的底物特异性 ,广泛的存在于机体各组织中 ,可能是Na+依赖的葡萄糖载体家族成员 ,由蛋白激酶C介导的通道调节 ,其基因位于人染色体 2p2 3。此转运体的发现为研究维生素缺乏病及如何促进维生素利用提供了新的途径
Vitamin utilization has always been a subject that scientists and medical workers are passionate about and has something to do with human health. It has now been found that the absorption of certain water-soluble vitamins is mediated by a proprietary transporter. This review summarizes the gene structure, protein structure, tissue distribution, the functional characteristics after cloning and expression, the regulation of chromosomal location and transport process, which are common to pantothenic acid, biotin and lipoic acid. The transporter is called as three vitamins Multi-vitamin transporter (SMVT), with obvious substrate specificity, is widely present in various tissues of the body and may be a member of the Na + -dependent glucose transporter family, mediated by protein kinase C, whose genes are located on the human chromosome 2p2 3. The discovery of this transporter provides a new way to study vitamin deficiency disorders and how to promote vitamin utilization