论文部分内容阅读
目的观察卡介苗多糖核酸注射液预防过敏性紫癜(HSP)复发的临床效果及相关因素分析。方法 82例HSP患儿随机分为治疗组46例和对照组36例,33例健康儿童作为正常对照组。对照组常规治疗,治疗组加卡介苗多糖核酸注射液肌注,0.5 mg,1周2次,疗程为3个月。观察1年内病情的反复、复发率及测定治疗前、治疗3个月后血CD3+,CD4+,CD8+,白介素-2(IL-2),γ-干扰素(IFN-γ),IgA水平。结果 HSP患儿治疗前血CD3+,CD4+,IL-2,IFN-γ水平均低于正常对照组(P<0.01),IgA明显上升(P<0.01),CD8+细胞水平各组间无明显差异(P>0.05),观察3个月后复查血CD3+,CD4+,CD8+,IL-2,IFN-γ,IgA水平,发现治疗组的各项指标恢复较对照组明显(P<0.05或<0.01),1年复发率明显下降(P<0.05)。结论卡介苗多糖核酸能调节HSP患儿免疫功能,能有效降低复发率。
Objective To observe the clinical effect of BCG-PSN in the prevention of the recurrence of Henoch-Schonlein purpura (HSP) and its related factors. Methods 82 cases of HSP were randomly divided into treatment group 46 cases and control group 36 cases, 33 healthy children as normal control group. Control group conventional treatment, the treatment group plus BCG injection of intramuscular injection of nucleic acid, 0.5 mg, 2 times a week for 3 months. The incidences of recurrence and relapse within 1 year were observed and the levels of CD3 +, CD4 +, CD8 +, IL-2, IFN-γ and IgA were measured before and 3 months after treatment. Results The levels of CD3 +, CD4 +, IL-2 and IFN-γ in the blood of the children with HSP before treatment were significantly lower than those in the normal control group (P <0.01) and IgA levels (P <0.01) The levels of CD3 +, CD4 +, CD8 +, IL-2, IFN- γ and IgA in blood were observed after 3 months. The indexes of the treatment group recovered more obviously than the control group (P <0.05 or <0.01) 1 year recurrence rate decreased significantly (P <0.05). Conclusion BCG polysaccharide nucleic acid can regulate immune function in children with HSP, can effectively reduce the recurrence rate.