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5. Inhibition of proteasome by bortezomib increase chemosensitivity of bcr/abl positive human k562 chro

Inhibition of proteasome by bortezomib increase chemosensitivity of bcr/abl positive human k562 chro

来源 :健康(英文) | 被引量 : 0次 | 上传用户：ylovew

【摘 要】

：

Chronic myeloid leukaemia (CML) results from a translocation between chromosomes 9 and 22 which generates the BCR/ABL fusion oncopro-tein. BCR/ABL has constitut

【作 者】

：

Baran Yusuf Coskun Oztekin Bas 

【机 构】

：

不详

【出 处】

：

健康(英文)

【发表日期】

：

2009年4期

【关键词】

：

IMATINIB BORTEZOMIB Combination Therapy CML BCR/ABL Imatinib Bortezomib Combinat 

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Chronic myeloid leukaemia (CML) results from a translocation between chromosomes 9 and 22 which generates the BCR/ABL fusion oncopro-tein. BCR/ABL has constitutively tyrosine kinase activity resulting in leukemogenesis. Imatinib, a competitive inhibitor o

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