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目的探讨慢性尿毒症(CRF)患者血清中甲状旁腺素(PTH)、血清铁蛋白(SF)和血清肌酐(CR)、尿素氮(BUN)、尿酸(UA)之间的相关性,为CRF疾病的进展和其并发症的发生进行有效评估和监测提供指导。方法随机收集232例CRF患者和232例健康体检者静脉血标本,采用电化学发光免疫法测定血浆PTH,化学发光免疫法检测SF水平,酶联速率测定法检测血清CR、BUN,尿酸酶法检测UA水平,同时分析PTH、SF与CR、BUN、UA的相关性。结果慢性尿毒症组PTH、SF、CR、BUN、UA水平均高于健康对照组,差异有统计学意义(P<0.01)。CRF患者血清PTH、SF水平与CR、BUN、UA水平呈正相关性(P<0.05)。结论 CRF患者体内PTH、SF及CR、BUN、UA明显升高,可作为预测CRF病情及其并发症监测的重要指标。
Objective To investigate the correlation between serum parathyroid hormone (PTH), serum ferritin (SF) and serum creatinine (CR), blood urea nitrogen (BUN) and uric acid (UA) in patients with chronic uremia (CRF) The progress of the disease and the occurrence of its complications provide guidance for effective assessment and monitoring. Methods Blood samples of 232 CRF patients and 232 healthy volunteers were randomly collected. Plasma PTH was measured by chemiluminescence immunoassay. SF was detected by chemiluminescence immunoassay. Serum CR, BUN and uricase UA levels, while PTH, SF and CR, BUN, UA correlation. Results The levels of PTH, SF, CR, BUN and UA in patients with chronic uremia were significantly higher than those in healthy controls (P <0.01). Serum levels of PTH and SF were positively correlated with CR, BUN and UA in patients with CRF (P <0.05). Conclusions The levels of PTH, SF, CR, BUN and UA in patients with CRF are significantly higher than those in patients with CRF, which may be used as an important index to predict the status of CRF and monitor its complications.