核因子κB(nuclear factor kappa B,NF-κB)的活化可促进其主要下游因子肿瘤坏死因子α(tumor necrosis factorα,TNF-α)的表达,TNF-α是早期炎症反应的重要介质。TNF的下游因子TRAF6是肿瘤坏死因子受体相关因子(tumor necrosis factor receptorassociated factors,TRAF)家族中唯一可以直接与 The activation of nuclear factor kappa B (NF-κB) can promote the expression of tumor necrosis factorα (TNF-α), a major downstream factor of TNF-α, which is an important mediator of early inflammatory reaction. TRAF6, the downstream factor of TNF, is the only one in the family of tumor necrosis factor receptor associated factors (TRAF)