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细胞色素氧化酶P4502C19(CYP2C19)又称S-美芬妥英羟化酶,其活性在人群分布中呈明显的遗传多态性。全文就近几年P4502C19的检测方法,基因多态性分子机制,基因多态性与药物和肿瘤易患性的关系等研究进展作一综述。
Cytochrome oxidase P4502C19 (CYP2C19), also known as S-mephenytoin hydroxylase, its activity in the population showed significant genetic polymorphism. In this paper, we review the recent progress in the detection of P4502C19, the molecular mechanism of polymorphism, the relationship between genetic polymorphism and drug and tumor susceptibility.