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作者提到,流行病学调查证明缺硒地区中人的结肠癌、直肠癌、乳腺癌及其它癌症发病率稍有上升,临床研究观察到,胃肠癌患者的血液硒水平较低。他曾以1,2-二甲基联氨(DMH)及其活性代谢产物-甲基氧化偶氮基甲醇(MAM),诱发结肠肿瘤进行动物模型实验。实验用雄性Sprague-Dawley大鼠,皮下注射DMH或MAM以诱发结肠肿瘤。其中一组在给DMH或MAM同时喂给加有4 ppm硒(亚硒酸钠)的饮水,20周以后发现给DMH同时补硒的大鼠结肠肿瘤发病率由87%降至
The authors note that epidemiological investigations have shown a slight increase in the incidence of colon, rectal cancer, breast cancer and other cancers in people with selenium deficiencies, and clinical studies have observed lower selenium levels in patients with gastrointestinal cancer. He used 1,2-dimethyl hydrazine (DMH) and its active metabolite - methyl azo methanol (MAM), induced colon tumor animal model experiments. Male Sprague-Dawley rats were experimentally injected with DMH or MAM subcutaneously to induce colon tumors. One group was given either DMH or MAM with 4 ppm selenium (sodium selenite) in drinking water at the same time. After 20 weeks, the incidence of colon cancer in rats receiving selenium supplementation with DMH was reduced from 87%