3β 羟基 1 7β 苯甲酰氧基 5α雄甾烷 ( 1 )是合成双炔失碳酯 (抗孕 53) [1] 、双氢睾丸素[2 ] 等激素类药物的关键中间体。 1是由 3β 乙酰氧基 1 7β 苯甲酰氧基 5α雄甾 ( 2 )水解而得。该反应的关键在于选择性水解。文献报道水解多选择碱性条件下进行 ,如在 0 .1ＮＮａＯ 3β hydroxy 1 7β benzoyloxy 5α androstane (1) is a key intermediate in the synthesis of an anordrin (anti-pregnancy 53) [1], dihydrogestosterone [2] and other hormonal drugs. 1 is derived from the hydrolysis of 3β-acetoxy-17β-benzoyloxy-5-androsta (2). The key to this reaction is selective hydrolysis. It has been reported in the literature that hydrolysis is carried out under alkaline conditions such as 0.1NNaO