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目的观察持续体内外循环热灌注联合化疗在治疗恶性胸腔积液的疗效。方法对确诊为恶性胸腔积液的48例肺癌、乳腺癌患者,先排尽胸腔积液,将体内外循环生理盐水或蒸馏水及化疗药升温至46℃,将其灌入胸腔内,使胸腔内温度恒温在44.5~45.5℃进行热疗,观察患者近期疗效。结果恶性胸腔积液明显减少或消失,呼吸困难、胸闷、咳嗽等症状明显好转,不良反应较小。结论持续体内外循环热灌注联合化疗对治疗恶性胸腔积液近期疗效确切,不良反应轻。
Objective To observe the efficacy of continuous intra-and extracorporeal circulation hyperthermic perfusion combined with chemotherapy in the treatment of malignant pleural effusion. Methods Forty-eight cases of lung cancer and breast cancer diagnosed as malignant pleural effusion were treated by excretion of pleural effusion. The physiological saline or distilled water and chemotherapeutic drugs in vivo and in vitro were warmed to 46 ℃, Temperature thermostat at 44.5 ~ 45.5 ℃ for hyperthermia, observe the short-term efficacy of patients. Results Malignant pleural effusion was significantly reduced or disappeared, dyspnea, chest tightness, cough and other symptoms improved significantly, with less adverse reactions. Conclusions Continuous thermal perfusion combined with external chemotherapy and chemotherapy for the treatment of malignant pleural effusion, the recent curative effect, adverse reactions.