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Background: Both periodontal disease and benign prostatic hyperplasia are age-related diseases that affect millions of people worldwide. Hence, this study aimed to investigate the association between periodontal disease and the risk of benign prostatic hyperplasia.Methods: A total of 4930 participants were selected from an available health examination that was carried out in 2017, only males were considered for further analysis. All eligible males were divided into benign prostatic hyperplasia and normal groups, the benign prostatic hyperplasia group was then divided into prostate volume ≤60 g and >60 g subgroups; all their periodontal status was extracted and then into normal (CPI score of 0), periodontal disease (CPI score between 1 and 4), and periodontitis (CPI score between 3 and 4) groups. The correlation between periodontal disease and benign prostatic hyperplasia was investigated using logistic regression analyses and greedy matching case-control analysis. Subgroup analysis based on prostate volume was also performed. All analyses were conducted with SAS 9.4 software. Results: A total of 2171 males were selected for this analysis. The presence of periodontal disease significantly increased the risk of benign prostatic hyperplasia by 1.68 times (OR=1.68, 95％ CI: 1.26–2.24), and individuals with periodontitis showed a higher risk (OR=4.18, 95％ CI: 2.75–6.35). In addition, among matched cases and controls, this association remained robust (periodontal disease: OR=1.85, 95％ CI: 1.30–2.64; periodontitis: OR=4.83, 95％ CI: 2.57–9.07). Subgroup analysis revealed that periodontal disease significantly increased benign prostate hyperplasia risk as well (for prostate volume ≤60 g: OR=1.64, 95％ CI: 1.22–2.20; for volume >60 g: OR=2.17, 95％ CI: 1.04–4.53), and there was a higher risk in the group with a prostate volume greater than 60 g. Conclusions: Periodontal disease is significantly and positively associated with an increased risk of benign prostatic hyperplasia. Further validation studies should be performed to explore the relationship between periodontal treatment and benign prostate hyperplasia.