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目的探讨特发性间质性肺炎(IIP)临床治疗。方法将40例IIP患者随机分为对照组(常规治疗)与观察组(乙酰半胱氨酸联合丹红治疗),比较两组预后。结果与治疗前比较,两组治疗后6min步行试验距离均有不同程度延长,血清IFN-γ指标有所升高,Ⅲ-C指标含量相对降低,差异均有统计学意义(P<0.05)。但观察组各项改善幅度均明显优于对照组(P<0.05)。对照组治疗前后SPO2评分及CT病变评分变化无差异(P>0.05),观察组用药后CT病变评分优于治疗前(P<0.05),SPO2评分相对改善。两组治疗后影像学、临床症状CRP评分均有改善,观察组各指标下降幅度显著优于对照组,差异有统计学意义(P<0.05)。结论依据IIP临床特点,在常规应用泼尼松治疗的基础上加用乙酰半胱氨酸联合丹红治疗,可显著改善预后,值得临床推广应用。
Objective To investigate the clinical treatment of idiopathic interstitial pneumonia (IIP). Methods Forty IIP patients were randomly divided into control group (conventional treatment) and observation group (acetylcysteine combined with Danhong treatment), and the prognosis was compared between the two groups. Results Compared with those before treatment, the distance between the two groups was prolonged at 6min after treatment, the level of serum IFN-γ was increased, and the content of Ⅲ-C was decreased. The difference was statistically significant (P <0.05). However, the improvements in the observation group were significantly better than the control group (P <0.05). The SPO2 score and CT lesion scores of the control group had no significant difference before and after treatment (P> 0.05). The CT lesion score of the observation group was better than that before treatment (P <0.05) and the SPO2 score was improved. After treatment, the CRP scores of both imaging and clinical symptoms were improved in both groups. The decline rate of each index in the observation group was significantly better than that in the control group, with significant difference (P <0.05). Conclusion According to the clinical features of IIP, adding acetylcysteine and Danhong to conventional treatment of prednisone can significantly improve the prognosis, which is worthy of clinical application.