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目的比较二黄新伤止痛凝胶膏剂与二黄新伤止痛软膏剂的体外透皮特性。方法采用Strat-M膜及改进的Franz扩散池进行体外透皮试验,用高效液相色谱法测定制剂中君药独活的有效成分蛇床子素含量为评价指标,比较凝胶膏剂与软膏剂两种剂型的透皮吸收特征。结果二黄新伤止痛凝胶膏剂的透皮回归曲线方程为Ln=0.004t+0.019,r=0.96;软膏的透皮回归曲线方程为Ln=0.002t+0.003,r=0.995。二黄新伤止痛凝胶膏剂的透皮率及透皮量均明显优于二黄新伤止痛软膏。结论凝胶膏剂透皮性能优于软膏剂,且不易过敏,贴敷更方便。
Objective To compare the in vitro transdermal properties of two yellow hurts analgesic gel ointment and two yellow hurts analgesic ointment. Methods The in vitro transdermal test was performed using Strat-M membrane and modified Franz diffusion cell. The content of Osthole in the preparation was determined by high performance liquid chromatography (HPLC) as the evaluation index. Compared with the gel ointment Transdermal absorption characteristics of the dosage form. Results The formula of transdermal regression curve of Erhuang Xinjian analgesic gel plaster was Ln = 0.004t + 0.019, r = 0.96. The transdermal regression equation of ointment was Ln = 0.002t + 0.003, r = 0.995. Two yellow new pain gel gel transdermal penetration rate and transdermal volume were significantly better than two yellow new pain relief ointment. Conclusion gel ointment transdermal performance is better than ointment, and not easy to allergy, the application more convenient.