他汀类药物独立于调脂外的作用,包括:抗氧化、调节一氧化氮合成与改善内皮功能、抑制炎症细胞因子、调节心脏自主神经功能和逆转心室重构等。这些“多效性作用”促进了它在缺血性和非缺血性慢性心力衰竭(心衰)中的应用[1]。近年来许多基础与临床研究表明,他汀类药物的这些作用 Statins are independent of lipid-lowering effects, including anti-oxidant, nitric oxide synthase, endothelial function, anti-inflammatory cytokines, cardiac autonomic nerve function and reversal of ventricular remodeling. These “pleiotropic effects” have promoted its use in ischemic and nonischemic chronic heart failure (HF) [1]. In recent years, many basic and clinical studies have shown that these effects of statins