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替加环素作为新型的甘氨酰环素类抗生素,具有独特的作用机制,其抗菌谱广泛、耐药率低,在成人中应用多见.由于替加环素对牙齿的不良反应和缺乏足够的儿童用药临床数据,儿童用药少见.随着多重耐药菌感染增加,在无其他可替代药物选择时,部分医师在儿童重症感染时选择超说明书应用替加环素.文章综述儿童替加环素的超说明书用药、药物剂量、安全性等.“,”Tigecycline is a new class of antimicrobials called glycylcyclines,which has been reported to have a specific antibacterial mechanism with a wide spectrum and low resistance rate.In adults,tigecycline safety and efficacy data were widely known.However,its use in children has been extremely limited because of lacking experience on its effects on tooth development and other clinical data in children.When no other alternative antibacterial agents could be chosen due to multidrugresistant bacterial infections,tigecycline would became an available approach to treat severe infections in children.This article offers an overview on tigecycline off-label uses,dosage and safety,and provides evidences for the choice of antibiotics in pediatric patients with severe infections.