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硝苯啶(Ⅰ)从血中消除很快,其抗高血压作用仅维持几小时,故将其制成缓释制剂以提高药物疗效。通过在硝苯啶或硝苯啶-聚乙二醇固体分散物中加入羟丙基甲基纤维素(HPMC),可制得多孔性亲水硝苯啶缓释片,其体外释药过程符合一级动力学行为.共试验了三种处方,各处方组成为:处方1 I0.020g,HPMC0.365g,滑石粉0.010g,硬脂酸镁0.005g;处方2 I-PEG6000固体分散物(1∶9)0.200g(内含I0.020g)HPMC
Nifedipine (I) is rapidly eliminated from the blood and its antihypertensive effect lasts only for a few hours, so it is made into a sustained-release preparation to improve the curative effect. Porous hydrophilic nifedipine sustained-release tablets can be prepared by adding hydroxypropyl methylcellulose (HPMC) to the solid dispersion of nifedipine or nifedipine-polyethylene glycol, the in vitro release process is consistent with First-order kinetic behavior. A total of three prescriptions were tested. The prescriptions consisted of: prescription 1 I0.020 g, HPMC 0.3565 g, talc 0.010 g, magnesium stearate 0.005 g; prescription 2 I-PEG 6000 solid dispersion : 9) 0.200g (containing I0.020g) HPMC