论文部分内容阅读
目的:探讨肥胖儿童非酒精性脂肪肝炎(nonalcoholic steatohepatitis,NASH)与脂肪因子的关系。方法:对符合NASH诊断的23例患儿、符合单纯性肥胖诊断的17例儿童以及20例正常儿童分别检测血丙氨酸氨基转移酶(ALT)、游离脂肪酸、瘦素、脂联素、肿瘤坏死因子(TNF-α),比较它们的水平并分析ALT与各指标的关系。结果:NASH组患儿游离脂肪酸、瘦素、TNF-α水平高于单纯肥胖组和对照组(P<0.05,P<0.01),而脂联素水平低于另两组(P<0.05,P<0.01)。相关分析显示:ALT与游离脂肪酸、瘦素、TNF-α各指标间存在正相关(r=0.407,P<0.01;r=0.338,P<0.05;r=0.372,P<0.05),与脂联素间存在负相关(r=-0.378,P<0.05)。结论:NASH患儿高血脂、高瘦素血症、高TNF-α单独或共同构成NASH的发病因素之一,而脂联素则起保护作用。
Objective: To investigate the relationship between nonalcoholic steatohepatitis (NASH) and adipokines in obese children. Methods: Twenty-three children who were diagnosed as NASH, 17 children who were diagnosed as simple obesity, and 20 normal children were tested for serum levels of ALT, free fatty acid, leptin, adiponectin, tumor Necrosis factor (TNF-α), compare their levels and analyze the relationship between ALT and each index. Results: The levels of free fatty acid, leptin and TNF-α in NASH group were higher than those in simple obesity group and control group (P <0.05, P <0.01), while the levels of adiponectin in NASH group were lower than those in the other two groups (P <0.05, P <0.01). Correlation analysis showed that there was a positive correlation between ALT and free fatty acids, leptin and TNF-α (r = 0.407, P <0.01; r = 0.338, P <0.05; There was a negative correlation between them (r = -0.378, P <0.05). Conclusions: Hyperlipidemia, hyperlipidemia and high TNF-α in NASH children alone or together constitute one of the pathogenesis of NASH, while adiponectin plays a protective role.