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目的观察硫辛酸联合前列地尔注射液治疗糖尿病周围神经病变的临床疗效。方法将80例糖尿病周围神经病变患者随机分为对照组(40例)和治疗组(40例),对照组单用前列地尔注射液;治疗组联合使用硫辛酸和前列地尔注射液,两组均连续治疗2w。结果对照组和治疗组总有效率分别为85.00豫和62.50豫,治疗组明显优于对照组(<0.05),治疗组神经传导速度改善的有效率明显高于对照组,差异有统计学意义(<0.01)。结论硫辛酸联合前列地尔注射液可有效改善糖尿病周围神经病变的临床症状及周围神经的感觉、运动传导速度。“,”Objective To observe clinical ef icacy of lipoic acid combined alprostadil injection in the treatment of diabetic peripheral neuropathy. Methods The 80 cases of diabetic peripheral neuropathy were randomly divided into control group (40 cases) and treatment group (40 cases), The control group used Alprostadil Injection;the treatment group combined with alpha lipoic acid and Alprostadil Injection, Two groups were treated for 2 weeks .Results The control group and the treatment group the total ef ective rate were 85.00%and 62.50%, the treatment group was significantly bet er than the control group ( < 0.05), the treatment group of nerve conduction velocity improvedef iciency is significantly higher than that in the control group, the dif erence was statistical y significant ( < 0.01). Conclusion Sensory, motor conduction velocity of clinical symptoms and nerve lipoic acid combined with Alprostadil Injection can ef ectively improve diabetic peripheral neuropathy.