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过去的文献报告耳蜗内电位依赖于代谢,当缺氧时,耳蜗内电位(EP)迅速下降,5分钟内可改变极性,2～4小时后此负电位可慢慢达到0位。在缺O_2的早期,内淋巴同时伴有Na~+升高,K~+降低。作者为研究缺氧时对耳蜗内电位和内淋巴K~+、Na~+浓度的影响,用三组豚鼠来观察,以确定缺氧早期负EP的性质。作者选用三组豚鼠:第一组为卡那霉素处理组,共14只,每天肌肉注射卡那霉素硫酸盐400mg/kg,连用两周,停药后4～5周进行试验。第二组舞蹈组,13只,均系由NIH供应的
Previous literature reports that the potential of the cochlea is dependent on metabolism. When hypoxia occurs, the intra-cochlear potential (EP) decreases rapidly and changes polarity within 5 minutes. After 2 to 4 hours, the negative potential slowly reaches zero. In the early lack of O2, endolymph accompanied by Na ~ + increased, K ~ + decreased. In order to study the effects of hypoxia on intracochlear potential and endogenous lymph K ~ + and Na ~ + concentrations, three groups of guinea pigs were used to observe the properties of negative EP during early hypoxia. The authors selected three groups of guinea pigs: the first group was kanamycin treatment group, a total of 14, intramuscular injection of kanamycin sulfate 400mg / kg, once every two weeks, 4 to 5 weeks after stopping the test. The second dance group, 13, were all supplied by the NIH