他汀类药物是羟甲基戊二酰辅酶A(HMG-CoA)还原酶的竞争性抑制剂,可抑制内源性胆固醇的合成和刺激低密度脂蛋白(LDL)受体的合成,临床上被广泛用来治疗高胆固醇血症。大量的研究发现,他汀类药物除了显著地降低胆固醇、抗动脉粥样硬化和心血管保护作用之外,还具有独立于此之外的其它作用,如肺、肾保护作用、延缓肾衰竭进展、抑制动脉瘤的形成和扩张作用、抗肿瘤作用、促进骨形成作用、促进伤口愈合作用、以及降低感染性休克的死亡风险等多方面的作用。 Statins are competitive inhibitors of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase and inhibit the synthesis of endogenous cholesterol and stimulate the synthesis of low density lipoprotein (LDL) receptors, which are clinically Widely used to treat hypercholesterolemia. A large number of studies have found that statins have other independent roles besides cholesterol, anti-atherosclerosis and cardiovascular protection significantly, such as lung and kidney protection, retarding the progression of renal failure, Inhibit the formation and expansion of aneurysms, anti-tumor effect, promote bone formation, promote wound healing, and reduce the risk of death from septic shock and many other roles.