目前共识建议指出对接受双联抗血小板治疗的患者给予质子泵抑制剂以降低胃肠道出血风险。但最近有研究表明,联用氯吡格雷质子泵抑制剂患者不良心血管事件高于单独使用氯吡格雷治疗者。现就质子泵抑制剂和氯吡格雷相互作用的争议和临床研究进展作一综述。 Current consensus recommendations indicate that patients receiving dual antiplatelet therapy are given proton pump inhibitors to reduce the risk of gastrointestinal bleeding. However, recent studies have shown that patients with clopidogrel proton pump inhibitor adverse cardiovascular events than clopidogrel alone treatment. Now the controversy and clinical research progress on the interaction between proton pump inhibitors and clopidogrel are reviewed.