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目的:优选胶艾汤中各药物的最佳炮制方法和提取方法。方法:取NIH雌性小鼠随机分为6组,即正常对照组、全方生品水煎组、部分炮制水煎组、全方炮制水煎组、全方炮制酒煮组、宫血宁组,ig给药,0.02 mL.g-1,每日1次,连续1周,以小鼠出血时间与凝血时间为指标,观察不同炮制和提取方法对胶艾汤止血作用的影响。结果:与正常对照组比较,全方炮制酒煮与全方炮制水煎组的出血时间与凝血时间非常显著缩短,部分炮制水煎组显著缩短,全方生品水煎组无明显变化。结论:止血作用强弱顺序是:全方炮制酒煮>全方炮制水煎>部分炮制水煎>全方生品水煎。胶艾汤应全方炮制后酒煮入药。
Objective: To optimize the best processing method and extraction method of various drugs in Jiaoyaitang. Methods: NIH female mice were randomly divided into 6 groups, namely, normal control group, all-round raw water decoction group, partially decocted decoction group, decoction all-round decoction group, all-brewed liquor group, Gongxuening group, ig Administration, 0.02 mL.g-1, once daily for 1 week, the bleeding time and clotting time were used as indexes to observe the effects of different processing and extraction methods on the hemostatic effect of Jiaoai Decoction. Results: Compared with the normal control group, the bleeding time and clotting time were significantly shortened in the whole recipe brewing and the whole recipe decoction decoction group, the partial decoction decoction group was significantly shortened, the whole recipe decoction did not change significantly. Conclusion: The order of hemostatic effect is as follows: whole-brewing brewing> all-process decoction> partial decoction decoction> all-round decoction. Plastic AI soup should be cooked after all brewed into medicine.