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目的比较眼底激光单用和联合雷珠单抗治疗糖尿病性视网膜病变的临床疗效。方法回顾性分析本院自2010年1月~2012年6月收治的DR患者临床资料,收集82例(均为单眼)随机分为两组,眼底激光单用组(A组)40例,激光联合雷珠单抗组(B组)42例。结果术后两组患者视力均显著提高,A组中30例CNV完全闭合,10例CNV大部分闭合。B组中35例CNV完全闭合,7例CNV大部分闭合。OCT显示两组患者术眼视网膜下液吸收,CNV强反射区明显缩小,黄斑区视网膜厚度显著减少,随访中无明显眼部及全身不良反应。结论在糖尿性视网膜病变的诊治中,采用激光联合雷珠单抗较激光单用更有利于患者视网膜内渗液的吸收,提高患者视力。
Objective To compare the clinical efficacy of fundus laser combined with ranibizumab in the treatment of diabetic retinopathy. Methods The clinical data of patients with DR treated in our hospital from January 2010 to June 2012 were retrospectively analyzed. 82 patients (all eyes were monocular) were randomly divided into two groups. Group A (40 eyes), laser group Combined with ranibizumab group (B group) 42 cases. Results The visual acuity of both groups was significantly increased after operation. Thirty CNVs in group A were completely closed and most of 10 CNVs were closed. In group B, 35 cases of CNV completely closed and 7 cases of CNV mostly closed. OCT showed subretinal fluid absorption in the two groups of patients, CNV reflex area was significantly reduced, macular retinal thickness was significantly reduced, no significant eye and systemic follow-up adverse reactions. Conclusion In the diagnosis and treatment of diabetic retinopathy, laser combined with ranibizumab laser is more conducive to the absorption of exudate in patients with retinal and improve visual acuity.