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选取初诊2型糖尿病患者80例,给与甘精胰岛素联合格列美脲治疗12周,比较治疗前后空腹血糖(FBG)、餐后2h血糖(2hGP)、空腹C肽(2hC-P)、糖化血红蛋白(HbA1C),同时观察肾功能的变化以及低血糖发生的次数。治疗后所有患者血糖、糖化血红蛋白均明显下降(P<0.01),空腹及餐后2hC-P均较治疗前增加(P<0.01),肝肾功能无明显变化,发生低血糖4例。甘精胰岛素联合格列美脲治疗初诊2型糖尿病有较好的疗效,方便安全,且胰岛素能得到部分恢复。
Eighty newly diagnosed type 2 diabetic patients were selected and treated with glargine and glimepiride for 12 weeks. Fasting blood glucose (FBG), postprandial blood glucose (2hGP), fasting C peptide (2hC-P) Hemoglobin (HbA1C), while observing changes in renal function and the frequency of hypoglycemia. After treatment, the blood glucose and HbA1c of all patients were significantly decreased (P <0.01), fasting and postprandial 2hC-P were increased compared with before treatment (P <0.01), no significant changes in liver and kidney function, hypoglycemia occurred in 4 cases. Glargine and glimepiride treatment of newly diagnosed type 2 diabetes have a better effect, convenient and safe, and insulin can be partially restored.