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1例70岁女性患者服用卡马西平治疗癫痫。2周后因效果不佳换用加巴喷丁(首日300 mg,1次/d;第2天开始300 mg,2次/d)。1个月后,患者进食烧烤食物后出现上腹部疼痛。实验室检查:丙氨酸转氨酶(ALT)403 U/L,天冬氨酸转氨酶(AST)740 U/L,乳酸脱氢酶(LDH)601 U/L,碱性磷酸酶(ALP)161 U/L,γ-L-谷氨酰转移酶(γ-GT)295 U/L。停用加巴喷丁,给予保肝治疗。1周后复查,ALT 38 U/L,AST 19 U/L,LDH 143 U/L,ALP 146 U/L,γ-GT 134 U/L。
A 70-year-old female patient took carbamazepine for the treatment of epilepsy. After 2 weeks, gabapentin (300 mg on the first day, once / d on the first day; 300 mg twice daily on the second day) was switched to ineffective treatment. After 1 month, the patient experienced upper abdominal pain after eating the grilled food. Laboratory tests included: alanine aminotransferase (ALT) 403 U / L, aspartate aminotransferase (AST) 740 U / L, lactate dehydrogenase LDU 601 U / L, alkaline phosphatase (ALP) 161 U / L, γ-L-glutamyl transferase (γ-GT) 295 U / L. Disable gabapentin, give liver protection treatment. One week later, ALT was 38 U / L, AST 19 U / L, LDH 143 U / L, ALP 146 U / L, and γ-GT 134 U / L.