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目的分析乌司他丁对改善心脏骤停后综合征全身炎症反应的有效性。方法 40例接受心脏骤停后综合征治疗的患者,随机分为对照组和试验组,每组20例,对照组患者仅进行综合治疗,试验组患者在综合治疗的基础上增加乌司他丁治疗,观察并比较两组疗效及血白细胞介素-6(IL-6)和血干扰素-α抗体(INF-α)的改善情况。结果试验组总有效率65.00%明显高于对照组的40.00%;试验组治疗后6 h和12 h INF-α浓度、IL-6浓度明显低于对照组,两组比较差异均有统计学意义(P<0.05)。结论乌司他丁治疗心脏骤停后综合征相对于单纯的综合性治疗临床效果上具有明显的优势,值得临床应用并推广。
Objective To analyze the effectiveness of ulinastatin in improving the systemic inflammatory response after cardiac arrest syndrome. Methods Forty patients undergoing cardiac arrest syndrome were randomly divided into control group and experimental group, with 20 cases in each group. Patients in control group were treated only with combined therapy. Patients in experimental group were given ulinastatin The curative effect and the improvement of interleukin-6 (IL-6) and interferon-α antibody (INF-α) in both groups were observed and compared. Results The total effective rate in the experimental group was 65.00%, which was significantly higher than that in the control group (40.00%). The concentrations of INF-α and IL-6 in the experimental group were significantly lower than those in the control group at 6 and 12 h (P <0.05). Conclusion Ulinastatin treatment of cardiac arrest syndrome relative to the simple comprehensive treatment of clinical effect has obvious advantages, it is worthy of clinical application and promotion.