目的　了解兔胸部火器伤血浆中肾上腺素 (epinephrine ,E)和去甲肾上腺素 (nore pinephrine ,NE )变化规律及在伤后应激反应中的作用。　方法　将 2 4只家兔随机分为 :单纯胸腔贯穿伤组 (A组 )、假致伤组 (B组 )和正常对照组 (C组 )。射击前A、B组右颈总动脉及右颈外静脉插管、C组耳中动、静脉头皮针穿刺接八道生理记录仪测压。伤前 5min、伤后 5 ,30min、1,3,6 ,12 ,2 4h取动脉血 2ml离心出血浆 ,采用高效液相色谱仪 (high -performanceliquidchromatography,HPLC)与电化学分析 (electrochemicaldetection ,ED)检测E及NE含量。　结果　 (1)A组E及NE于伤后 30min达伤前 4.13和 3.45倍 ,分别于伤后 1,3h降至最低点 ,为伤前 2 .5 7和 0 .47倍 ,于 6h达第二高峰 ,为伤前 4.14和 3.6 8倍 ,2 4h后降至伤前水平 ;B、C组E及NE比较 ,差异无显著性意义 (P >0 .0 5 )。(2 )A组动、静脉压致伤瞬间 (2ms内 )升高 ,平均达伤前的 1.8和 6 .8倍 ,迅即下降至伤前水平 ,随后缓慢下降 ,分别于伤后 30 ,5min降至最低点 (伤前的 0 .6 3和 0 .2 5倍 ) ,之后缓慢回升 ,6 ,12h接近伤前水平 ;B、C组动、静脉压比较 ,差异无统计学意义 (P >0 .0 5 )。　结论　兔胸部火器伤后血浆中E和NE均显著升高 ;二者浓度变化主要源自创伤后失? Objective To investigate the changes of epinephrine (E) and norepinephrine (NE) in the plasma of chest firearm and their roles in post-traumatic stress response. Methods Twenty-four rabbits were randomly divided into three groups: group A (simple thoracic trauma), sham group (group B) and control group (group C). Before the shooting, the right common carotid artery and the right external jugular vein were cannulated in group A and group B, and the pressure was measured by physiological scoring device in the C group. The plasma was extracted 5 min before injury, 5 min, 30 min, 1, 3, 6, 12, 24 h after injury by centrifugation. The plasma was separated by high-performance liquid chromatography (HPLC) and electrochemical detection (ED) Detection of E and NE content. Results (1) E and NE of group A were 4.13 and 3.45 times pre-injury at 30min after injury, respectively, and dropped to the lowest point at 1 and 3 hours after injury, respectively, at 2.57 and 0.47 times of pre-injury, Peaked at 4.14 and 3.6 times of pre-injury respectively, and dropped to the pre-injury level after 24 hours. There was no significant difference between E and NE in group B and C (P> 0.05). (2) In group A, venous pressure injury increased instantly (within 2ms), reaching an average of 1.8 and 6.8 times before injury, then decreased to pre-injury level and then decreased slowly, dropping 30 and 5 minutes after injury respectively (0.63 and 0.52 times before injury), and then recovered slowly, approaching the pre-injury level at 6 and 12 hours. There was no significant difference in arterial pressure and venous pressure between groups B and C (P> 0 .0 5). Conclusions After thorax and firearm wound, the E and NE levels in plasma increased significantly. The changes of the two concentrations mainly originated from the trauma.