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[目的]检测血管内皮生长因子(VEGF)和膜型基质金属蛋白酶-1(MT1-MMP)在口腔鳞状细胞癌(OSCC)中的表达,并探讨其意义。[方法]采用免疫组织化学SP法检测VEGF、MT1-MMP在40例OSCC和10例口腔正常黏膜组织中的表达。[结果]VEGF和MT1-MMP在OSCC组织中的阳性表达率分别为67.50%和75.00%,在正常口腔黏膜组织中均阴性表达,差异有显著性(P<0.001)。VEGF表达与OSCC的临床分期(P<0.05)及淋巴结转移显著相关(P<0.01),与肿瘤的分化程度无关。MT1-MMP表达与OSCC的分化程度(P<0.05)及淋巴结转移显著相关(P<0.01),但与肿瘤的临床分期无相关性。VEGF与MT1-MMP表达呈正相关(rs=0.650,P<0.001)。[结论]VEGF与MT1-MMP在OSCC发生发展中起重要作用,共同促进OSCC的浸润转移。
[Objective] To investigate the expression of vascular endothelial growth factor (VEGF) and membrane-type matrix metalloproteinase-1 (MT1-MMP) in oral squamous cell carcinoma (OSCC) [Method] The immunohistochemical SP method was used to detect the expression of VEGF and MT1-MMP in 40 cases of OSCC and 10 cases of oral normal mucosa. [Results] The positive rates of VEGF and MT1-MMP in OSCC tissues were 67.50% and 75.00%, respectively, which were all negatively expressed in normal oral mucosa tissues (P <0.001). There was a significant correlation between VEGF expression and clinical stage (P <0.05) and lymph node metastasis (P <0.01), but not with the degree of tumor differentiation. The expression of MT1-MMP was significantly correlated with the differentiation of OSCC (P <0.05) and lymph node metastasis (P <0.01), but not with the clinical stage of OSCC. The expression of VEGF and MT1-MMP was positively correlated (rs = 0.650, P <0.001). [Conclusion] VEGF and MT1-MMP play an important role in the occurrence and development of OSCC and promote the invasion and metastasis of OSCC.