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用S-100蛋白抗体ABC免疫组化法定量检测31例正常大肠粘膜、54例大肠腺瘤和144例大肠癌组织的树突状细胞(DC)。结果显示,大肠癌组织DC数量较正常大肠粘膜及腺瘤明显增多(P<0.01),DC数量和大肠癌的大体类型、组织学类型、浸润、转移及分期有关,术后生存期≥5年者癌组织DC明显多于(5年者(P<0.001)。表明DC在辅助机体抗肿瘤免疫反应中可能起一定作用,癌组织DC数量可作为估计预后的一项指标。
Quantitative detection of dendritic cells (DC) in 31 cases of normal colorectal mucosa, 54 cases of colorectal adenoma, and 144 cases of colorectal cancer tissue was performed by immunohistochemistry using S-100 protein antibody ABC. The results showed that the number of DCs in colorectal cancer tissue was significantly higher than that in normal colorectal mucosa and adenoma (P<0.01). The number of DC was related to the general type, histological type, invasion, metastasis, and staging of colorectal cancer, and the survival time was ≥ In 5 years, DCs were significantly more than those in 5 years (P<0.001), suggesting that DC may play a role in supporting the body’s anti-tumor immune response, and the number of DCs in cancer tissues may serve as an index to estimate prognosis.